Global Dual Orexin Receptor Antagonists Market to Reach $1.235 Billion by 2031, Growing at a CAGR of 7.14%

Dual orexin receptor antagonists are emerging as a major therapeutic direction in modern sleep medicine, leveraging the inhibition of OX1R and OX2R pathways to restore a more physiologic pattern of sleep initiation and maintenance. Their mechanism allows sleep to occur through the natural down-regulation of wakefulness signals rather than through central nervous system suppression, resulting in sleep architecture that more closely mirrors natural patterns. Supported by steady improvements in chemical design and manufacturing capabilities, the global supply chain—spanning Europe, Japan, the United States, and China—has formed a coordinated ecosystem of API producers and formulation manufacturers. Multiple commercial products are now available in major markets, each offering differentiated pharmacokinetic properties and improved tolerability for long-term use.

Clinically, these agents are being integrated into national and regional treatment guidelines, with adoption expanding across sleep clinics, psychiatry, and primary care settings. Shifts in patient demographics, including rising chronic insomnia and aging populations, have strengthened the demand for agents with favorable safety profiles and minimal risk of dependence or withdrawal. The growing prevalence of sleep disruption associated with stress, anxiety, or mood disorders is also accelerating market uptake. Continued accumulation of long-term safety and real-world evidence by leading manufacturers has strengthened the regulatory position of DORAs, and reimbursement inclusion in several markets has further driven prescription growth and accessibility.

Looking ahead, dual orexin receptor antagonists are expected to play an expanded role in sleep disorders linked to psychiatric conditions, neurodegenerative diseases, and chronic pain, offering broader therapeutic value beyond primary insomnia. Next-generation compounds with optimized receptor selectivity, refined half-life control, and improved delivery technologies are likely to further enhance nighttime stability and minimize next-day residual effects. With increasing participation from Chinese manufacturers in API and formulation development, the global production network will become more robust and cost-competitive, supporting broader clinical adoption and positioning DORAs as a major engine of innovation and market growth in the global sleep-medicine landscape.

According to the new market research report "Global Dual Orexin Receptor Antagonist Sleeping Pills Market 2025 by Manufacturers, Regions, Type and Application, Forecast to 2031", published by Global Info Research, the global Dual Orexin Receptor Antagonist Sleeping Pills market size is projected to grow from USD 670 million in 2024 to USD 1235 million by 2031, at a CAGR of 7.14% during the forecast period.

 

 

 

According to Global Info Research Top Players Research Center, the global key manufacturers of Dual Orexin Receptor Antagonist Sleeping Pills include Merck, Eisal, etc. In 2024, the global top three players had a share approximately 79.7% in terms of revenue.

 

 

Dual Orexin Receptor Antagonist Sleeping Pills Report Chapter Summary:
Chapter 1: Dual Orexin Receptor Antagonist Sleeping Pills Industry Definition and Market Overview
This chapter clearly defines the product definition, characteristics, and industry statistical scope of Dual Orexin Receptor Antagonist Sleeping Pills, systematically introduces its mainstream product classifications and key application areas, and presents the overall size and future outlook of the global market.
Chapter 2: In-depth Analysis of Core Dual Orexin Receptor Antagonist Sleeping Pills Companies (2021-2025)
This chapter focuses on the main players in the Dual Orexin Receptor Antagonist Sleeping Pills market. For each representative company, it not only introduces its basic overview, main business, and product portfolio, but also highlights its core operating data in the Dual Orexin Receptor Antagonist Sleeping Pills field, including sales volume, sales revenue, pricing strategies, and the latest development trends of the company from 2021 to 2025.
Chapter 3: Global Competitive Landscape Analysis (2021-2025)
This chapter examines the global Dual Orexin Receptor Antagonist Sleeping Pills competitive landscape from a macro perspective. By comparing the Dual Orexin Receptor Antagonist Sleeping Pills sales volume, pricing, revenue, and market share of major companies from 2021 to 2025, it quantitatively analyzes market concentration and interprets the competitive strategies and market position evolution of core manufacturers.
Chapter 4: Dual Orexin Receptor Antagonist Sleeping Pills Major Regional Market Size and Prospects (2021-2032)
This chapter conducts a regional-level analysis of the global Dual Orexin Receptor Antagonist Sleeping Pills core markets. It will present historical data on the Dual Orexin Receptor Antagonist Sleeping Pills market size (sales volume and revenue from 2021-2025) in major regions such as North America, Europe, and Asia Pacific, and provide market outlook forecasts for 2026-2032.
Chapter 5: Dual Orexin Receptor Antagonist Sleeping Pills Product Type Segmentation Market Forecast (2021-2032)
This chapter delves into the Dual Orexin Receptor Antagonist Sleeping Pills product structure. It will segment the Dual Orexin Receptor Antagonist Sleeping Pills market by different types (such as Suvorexant、 Lemborexant、 Daridorexant, etc.), and analyze in detail the historical market size of each segmented product category from 2021 to 2025 and the future growth trends from 2026 to 2032.
Chapter 6: Dual Orexin Receptor Antagonist Sleeping Pills Application Field Segmentation Market Forecast (2021-2032)
This chapter delves into the downstream application demand for Dual Orexin Receptor Antagonist Sleeping Pills. The market will be segmented by different application areas (such as Hospital and Clinic、 Retail Pharmacies、 Other, etc.), presenting the historical market size for each area from 2021-2025 and future demand forecasts from 2026-2032.
Chapters 7-11: In-depth Analysis of Global Regional Markets (2021-2032)
This section is the core module of the Dual Orexin Receptor Antagonist Sleeping Pills report, providing an in-depth country/regional analysis across five major regions: North America, Europe, Asia Pacific, South America, and the Middle East & Africa. The chapter structure for each region is consistent:
Segmentation by Country/Region: Analysis of the market size and forecasts for major countries within the region from 2021-2032.
Segmentation by Product Type: Presentation of the market structure and development forecasts for different product types within the region from 2021-2032.
Segmentation by Application Area: Analysis of market demand and prospects for different application areas within the region from 2021-2032.
Chapter 12: Global Dual Orexin Receptor Antagonist Sleeping Pills Market Dynamics, Challenges, and Trends
This chapter aims to analyze the key internal and external factors affecting the development of the Dual Orexin Receptor Antagonist Sleeping Pills market. It systematically reviews the core drivers of Dual Orexin Receptor Antagonist Sleeping Pills market growth, the main obstacles and challenges faced, and assesses future product, technology, and market development trends.
Chapter 13: Dual Orexin Receptor Antagonist Sleeping Pills Industry Chain Structure Analysis
This chapter analyzes the entire industry chain ecosystem of the Dual Orexin Receptor Antagonist Sleeping Pills industry. From upstream raw material supply to midstream production and manufacturing, and then to downstream end-use applications, it analyzes the current status, cost structure, and collaborative relationships of each link.
Chapter 14: Sales Channel Model Research
This chapter focuses on the distribution channels of Dual Orexin Receptor Antagonist Sleeping Pills products. It analyzes the market share, advantages and disadvantages, and typical cases of mainstream sales channels, and explores the innovation and development trends of channel models.
Chapter 15: Research Conclusions and Strategic Recommendations
As a summary of the report, this chapter will distill the core findings and conclusions of the entire report and, based on a comprehensive understanding of the Dual Orexin Receptor Antagonist Sleeping Pills market, provide actionable strategic development recommendations for industry participants and potential entrants.

 

For more information, please refer to "Global Dual Orexin Receptor Antagonist Sleeping Pills Market 2026 by Manufacturers, Regions, Type and Application, Forecast to 2032". This report analyzes the supply and demand situation, development status, and changes in the industry, focusing on the development status of the industry, how to face the development challenges of the industry, industry development suggestions, industry competitiveness, and industry investment analysis and trend forecasts. The report also summarizes the overall development dynamics of the industry, including the impact of the latest US tariffs on the global supply chain, the supply relationship analysis of the industrial chain, and provides reference suggestions and specific solutions for the industry in terms of products.